ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking.
Chu-Hsuan ChiuChin-Feng HsuanShih-Hua LinYi-Jen HungChii-Min HwuSiow-Wey HeeShu-Wha LinSitt-Wai FongPatrick Ching-Ho HsiehWei-Shun YangWei-Chou LinHsiao-Lin LeeMeng-Lun HsiehWen-Yi LiJou-Wei LinChih-Neng HsuVin-Cent WuGwo-Tsann ChuangYi-Cheng ChangLee-Ming ChuangPublished in: Journal of biomedical science (2023)
RRBP1 deficiency in mice caused hyporeninemic hypoaldosteronism, resulting in lower blood pressure, severe hyperkalemia, and sudden cardiac death. In juxtaglomerular cells, deficiency of RRBP1 reduced renin intracellular trafficking from ER to Golgi apparatus. RRBP1 is a brand-new regulator of blood pressure and potassium homeostasis discovered in this study.
Keyphrases
- blood pressure
- hypertensive patients
- endoplasmic reticulum
- heart rate
- binding protein
- induced apoptosis
- reactive oxygen species
- estrogen receptor
- signaling pathway
- blood glucose
- breast cancer cells
- early onset
- replacement therapy
- transcription factor
- metabolic syndrome
- high fat diet induced
- cell proliferation
- oxidative stress
- insulin resistance
- angiotensin ii