Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway.

Yang YangZongze YaoJiazhen ZhangWei ShaoBo LiHuihui WuWenjian TangJing Zhang

Published in: Infection and drug resistance (2024)

may act as a novel inhibitor of PG hydrolyse, disrupting autolysin-mediated PG homeostasis, and reducing inflammation by down-regulating the MDP-NOD2 pathway.

Keyphrases

oxidative stress
staphylococcus aureus
methicillin resistant staphylococcus aureus
signaling pathway
innate immune
mouse model
cell wall