The prevalence and mechanisms of heteroresistance to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae.

Xiaotuan ZhangWeiliang ZengJingchun KongZeyu HuangHongyun ShuMiran TangChangrui QianChunquan XuZhexiao MaJianzhong Ye

Published in: The Journal of antimicrobial chemotherapy (2024)

Ceftazidime/avibactam heteroresistance, primarily driven by pre-existing KPC variants, underscores the importance of considering heteroresistance in ceftazidime/avibactam therapeutics. Awareness of these dynamics is crucial for the effective and sustainable clinical application of ceftazidime/avibactam.

Keyphrases

klebsiella pneumoniae
gram negative
multidrug resistant
escherichia coli
risk factors
small molecule
dna methylation