TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Aitor Esparza-BaquerIbone LabianoOmar SharifAloña Agirre-LizasoFiona OakleyPedro M RodriguesEkaterina ZhuravlevaColm J O'RourkeElizabeth HijonaRaul Jimenez-AgüeroIoana RiañoAna LandaAdelaida La CastaMarco Y W ZakiPatricia Munoz-GarridoMikel AzkargortaFelix ElortzaAndrea VogelGernot SchabbauerPatricia AspichuetaJesper B AndersenSylvia KnappDerek A MannLuis BujandaJesus Maria BanalesMaria Jesus PerugorriaPublished in: Gut (2020)
TREM-2 plays a protective role in hepatocarcinogenesis via different pleiotropic effects, suggesting that TREM-2 agonism should be investigated as it might beneficially impact HCC pathogenesis in a multifactorial manner.