DNase Treatment Prevents Cerebrospinal Fluid Block in Early Experimental Pneumococcal Meningitis.
Chiara PavanAnna Lenice Ribeiro XavierMarta RamosJane FisherMarios KritsilisAdam LinderPeter BentzerMaiken NedergaardIben LundgaardPublished in: Annals of neurology (2021)
This study suggests that CSF accumulation is responsible for cerebral edema formation and identifies the glymphatic system and NETs as possible new treatment targets in S pneumoniae meningitis. ANN NEUROL 2021;90:653-669.