A novel potential target of IL-35-regulated JAK/STAT signaling pathway in lupus nephritis.

Zhe CaiSong ZhangPing WuQi RenPing WeiMing HongYu FengChun Kwok WongHong TangHuasong Zeng

Published in: Clinical and translational medicine (2021)

Our study provided a reference proteomic map of urinary biomarkers for JSLE-LN and elucidated evidence that IL-35 may regulate the interactive network of LAIR1-PTPN11-JAK-STAT-FN1 to affect JAK/STAT and MAPK signaling pathways to alleviate inflammation in JSLE-LN. This finding may provide a further prospective mechanism for JSLE-LN clinical treatment.

Keyphrases

signaling pathway
pi k akt
oxidative stress
induced apoptosis
epithelial mesenchymal transition
cell proliferation
risk assessment
human health
climate change
combination therapy
label free
network analysis