Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene.
Jake RogersFeng ChenDavor StanicFarheen FarzanaShanshan LiAriel M Zeleznikow-JohnstonJess NithianantharajahLeonid ChurilovPaul A AdlardLaurence LanfumeyAnthony J HannanThibault RenoirPublished in: British journal of pharmacology (2019)
Our study is the first evidence of reduced hippocampal LTP in SERT HET mice. We also show that functional SERT is required for exercise-induced increase in adult neurogenesis. Paradoxically, exercise had a negative impact on hippocampal-dependent cognitive tasks, especially in SERT HET mice. Taken together, our results suggest unique complex interactions between exercise and altered 5-HT homeostasis.
Keyphrases
- high intensity
- high fat diet induced
- cerebral ischemia
- physical activity
- resistance training
- working memory
- insulin resistance
- metabolic syndrome
- adipose tissue
- early onset
- mild cognitive impairment
- multiple sclerosis
- dna methylation
- temporal lobe epilepsy
- copy number
- subarachnoid hemorrhage
- white matter
- brain injury
- blood brain barrier