Development of a sheep model of atrioventricular block for the application of novel therapies.

Melad FarrahaJuntang LuIvana TrivicMichael Anthony Tony BarryJames ChongSaurabh KumarEddy Kizana

Published in: PloS one (2020)

We have successfully developed, characterized and validated a large animal model of atrioventricular block that is stable and technically feasible in adult sheep. This model will allow for the advancement of novel therapies, including the development of cell and gene-based therapies.

Keyphrases

single cell
genome wide
gene expression
mesenchymal stem cells
young adults
dna methylation
atrial fibrillation