A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Bin ZhangYuemang YaoAnne-Sophie CornecKillian OukoloffMichael J JamesPyry KoivulaJohn Q TrojanowskiAmos B SmithVirginia M-Y LeeCarlo BallatoreKurt R Brunden

Published in: Molecular neurodegeneration (2018)

A brain-penetrant MT-stabilizing TPD can safely correct MT and axonal deficits in an established mouse model of tauopathy, resulting in reduced tau pathology.

Keyphrases

mouse model
resting state
spinal cord injury
white matter
cerebrospinal fluid
functional connectivity
traumatic brain injury
cerebral ischemia
oxidative stress