Influence of Slco2b1-knockout and SLCO2B1-humanization on coproporphyrin I and III levels in rats.
Jonny KinziJanine HussnerAnima M SchaeferAndrea TreyerIsabell SeibertAnnika TillmannVanessa MuellerClarisse GherardiCelina VonwylMatthias HamburgerHenriette E Meyer Zu SchwabedissenPublished in: British journal of pharmacology (2023)
Our findings support that factors other than OATP1B-transporters are of relevance for basal CP levels. Only in female rats, humanization of SLCO2B1 affects basal CPI and CPIII serum levels, despite isomer selectivity of OATP2B1.
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