Inflammatory monocytes and microglia play independent roles in inflammatory ictogenesis.
Charles L HoweReghann G LaFrance-CoreyBrittany L OverleeRenee K JohnsonBenjamin D S ClarksonEmma N GodderyPublished in: Journal of neuroinflammation (2022)
PFU TMEV. Inoculation conditions that drive inflammatory monocyte infiltration resulted in robust behavioral seizures and EEG abnormalities, but the low inoculum condition, associated with only microglial activation, drove a more subtle seizure and EEG phenotype.