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Continuing Burden of Refractory Epilepsy.

Marnie T JansonJacquelyn L Bainbridge
Published in: The Annals of pharmacotherapy (2020)
Epilepsy is one of the most common neurological diseases, and uncontrolled seizures remain a significant problem for one-third of patients with epilepsy on drug therapy. Ongoing seizures affect the morbidity and mortality of patients with epilepsy. Premature death is up to 3 times higher in those with epilepsy than in the general population. Quality of life is affected by refractory epilepsy with physical, social, and psychological consequences. Patients may be stigmatized by society, institutions, and their own shame surrounding seizures. Questions remain on how to treat refractory epilepsy, also called drug-resistant, pharmacoresistant, or intractable epilepsy. Cenobamate, a novel antiseizure medication, may provide additional benefit for refractory epilepsy treatment.
Keyphrases
  • drug resistant
  • temporal lobe epilepsy
  • healthcare
  • mental health
  • end stage renal disease
  • physical activity
  • chronic kidney disease
  • stem cells
  • newly diagnosed
  • prognostic factors
  • acinetobacter baumannii