Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan.
Arash GhodousiAlamdar Hussain RizviAurangzaib Quadir BalochAbdul GhafoorFaisal Masood KhanzadaMehmood QadirEmanuele BorroniAlberto TrovatoSabira TahseenDaniela Maria CirilloPublished in: Antimicrobial agents and chemotherapy (2019)
We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment. This study underlines the relevance of surveillance programs following the introduction of new drugs.
Keyphrases
- drug resistant
- multidrug resistant
- acinetobacter baumannii
- mycobacterium tuberculosis
- public health
- end stage renal disease
- ejection fraction
- tertiary care
- pulmonary tuberculosis
- mesenchymal stem cells
- emergency department
- prognostic factors
- bone marrow
- human immunodeficiency virus
- drug induced
- hiv infected
- hepatitis c virus
- sensitive detection
- electronic health record
- combination therapy
- antiretroviral therapy