Login / Signup

Synergetic effect of high dose rate radiations (10× FFF/2400 MU/min/10 MV x-rays) and paclitaxel selectively eliminates melanoma cells.

Niraj LodhiPoonam NagpalSreeja SarojiniMichaela KeckYuk Ming ChiuZeenath ParvezLaura AdrianzenK Stephen Suh
Published in: Cancer reports (Hoboken, N.J.) (2022)
Our study indicates that radiations with paclitaxel have a potential synthetic lethal effect on melanoma cells and can be developed as a melanoma therapy without toxicities or harmful effects on normal primary skin cells.
Keyphrases
  • high dose
  • induced apoptosis
  • cell cycle arrest
  • low dose
  • oxidative stress
  • stem cells
  • cell death
  • mesenchymal stem cells
  • cell proliferation
  • human health
  • wound healing
  • chemotherapy induced
  • bone marrow
  • skin cancer