Synergetic effect of high dose rate radiations (10× FFF/2400 MU/min/10 MV x-rays) and paclitaxel selectively eliminates melanoma cells.
Niraj LodhiPoonam NagpalSreeja SarojiniMichaela KeckYuk Ming ChiuZeenath ParvezLaura AdrianzenK Stephen SuhPublished in: Cancer reports (Hoboken, N.J.) (2022)
Our study indicates that radiations with paclitaxel have a potential synthetic lethal effect on melanoma cells and can be developed as a melanoma therapy without toxicities or harmful effects on normal primary skin cells.