Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment.

Jeremy HarperMengzhen LiuStephen M MaloneMatt McGueWilliam G IaconoScott I Vrieze

Published in: Psychological medicine (2021)

Evidence suggests that multivariate endophenotypes of decision-making (P3/δ) and cognitive/attentional control (θ/antisaccade error) relate to alcohol/nicotine, schizophrenia, and educational attainment PGSs and represent promising targets for future research.

Keyphrases

bipolar disorder
decision making
data analysis
healthcare
working memory
smoking cessation
current status
quality improvement
alcohol consumption