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Platelet-associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity.

Joan Duran-BertranElena Cristina RusuAndrea Barrientos-RiosalidoLaia BertranRazieh MahmoudianCarmen AguilarDavid RiescoSalomé MartínezJavier Ugarte ChicoteFàtima SabenchCristóbal RichartTeresa Auguet
Published in: European journal of clinical investigation (2023)
Some platelet-related indices vary depending on liver condition. Here, we reported decreased MPV in MASLD presence. Moreover, we presented for the first time a predictive model using MPV, ALT levels and the presence of diabetes mellitus and metabolic syndrome to predict MASLD in obese women. Also, MPV is closely related to early liver inflammation in NASH, and PLA and PCT are related to hepatic ballooning. These indices could be widely used for the early detection of NASH since they are usually determined in routine laboratory tests.
Keyphrases
  • metabolic syndrome
  • insulin resistance
  • type diabetes
  • weight loss
  • adipose tissue
  • bariatric surgery
  • skeletal muscle
  • physical activity
  • body mass index
  • drug induced
  • high fat diet induced