Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity.

Chiao-Ling Tsai Po-Sheng Yang Feng-Ming Hsu Ann-Lii ChengWan-Ni YuJason Chia-Hsien Cheng

Published in: Journal of clinical and translational hepatology (2023)

TOP1i reinforces NK cell-activated anti-HCC effect of RT through RNF144A mediated DNA-PKcs ubiquitination. RNF144A provides a reason for differentiating radiosensitization effect between HCC cells.

Keyphrases

nk cells
circulating tumor
cell free
dna damage response
induced apoptosis
single molecule
cell cycle arrest
signaling pathway
magnetic resonance
cell death
oxidative stress
dna damage
computed tomography