Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury.

Victoria L DiBonaWenxin ZhuMihir K ShahAditi RafaliaHajer Ben CheikhDavid P Crockett Huaye Zhang

Published in: Journal of neuroinflammation (2019)

Together, our studies show that loss of Par1b/MARK2 switches microglia from a surveillant to a primed state during development, resulting in an increased neuroinflammatory response to insults.

Keyphrases

inflammatory response
neuropathic pain
white matter
resting state
spinal cord injury
multiple sclerosis
functional connectivity