Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia.

Yingjie QingXiangyuan WangHongzheng WangPo HuHui LiXiaoxuan YuMengyuan ZhuZhanyu WangYu ZhuJingyan XuQinglong GuoHui Hui

Published in: Cell communication and signaling : CCS (2021)

Our study indicated a special mechanism involving the regulation of P-TEFb kinase activity in CML cells, providing evidences for further application of wogonin in CML clinical treatment. Video Abstract.

Keyphrases

chronic myeloid leukemia
induced apoptosis
cell cycle arrest
cancer therapy
endoplasmic reticulum stress
protein kinase
drug delivery