Abnormalities of hippocampus and frontal lobes in heart failure patients and animal models with cognitive impairment or depression: A systematic review.
Ziwen LuYu TengLei WangYangyang JiangTong LiShiqi ChenBaofu WangYang LiJingjing YangXiaoxiao WuWeiting ChengXiangning CuiMingjing ZhaoPublished in: PloS one (2022)
30 studies were included, involving 17 pieces of clinical research on HF patients and 13 studies of HF animal models. In HF patients, the hippocampal injuries were shown in the reduction of volume, CBF, glucose metabolism, and gray matter, which were mainly observed in the right hippocampus. The frontal damages were only in reduced gray matter and have no difference between the right and left sides. The included HF animal model studies were generalized and demonstrated the changes in inflammation and apoptosis, synaptic reduction, and neurotransmitter disorders in the hippocampus and frontal lobes. The results of HF animal model studies complemented the clinical observations by providing potential mechanistic explanations of the changes in the hippocampus and frontal lobes.
Keyphrases
- cognitive impairment
- ejection fraction
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- oxidative stress
- working memory
- case control
- cerebral ischemia
- prefrontal cortex
- prognostic factors
- depressive symptoms
- patient reported outcomes
- signaling pathway
- climate change
- physical activity
- subarachnoid hemorrhage
- pi k akt