Management and treatment of cardiotoxicity due to anticancer drugs: 10 questions and answers.
Michela ChiancaIacopo FabianiAnnamaria Del FrancoChrysanthos GrigoratosAlberto AimoGiorgia PanichellaAlberto GiannoniVincenzo CastiglioneFrancesco GentileClaudio PassinoCarlo Maria CipollaDaniela Maria CardinaleMichele EmdinPublished in: European journal of preventive cardiology (2022)
Since the introduction of anthracyclines into clinical practice in the 1960s, chemotherapy has always been associated with cardiotoxicity. Patients on cardiotoxic drugs can develop a wide range of cardiovascular diseases, including left ventricular (LV) systolic dysfunction and heart failure (HF), arrhythmias, hypertension, and coronary artery disease (CAD). The rising number of cancer patients, population ageing, and the frequent overlap of cardiovascular and oncological diseases have highlighted the importance of close collaboration between cardiologists and oncologists. As a result, in 1995, cardiologists at the IEO (European Institute of Oncology) coined the term cardioncology, a new discipline focused on the dynamics of cardiovascular disease in cancer patients. Given the complex scenario characterized by a constant dialogue between the oncological condition and cardiovascular comorbidity, it is essential for the clinician to get the knowledge to properly fulfill the needs of the oncological patient under cardiotoxic treatment. Through the answer to 10 questions, we aim to describe the complex issue of cardiotoxicity by addressing the main critical points and current evidence related to the assessment, management, treatment, and surveillance of cancer patients under chemotherapy.
Keyphrases
- cardiovascular disease
- heart failure
- left ventricular
- coronary artery disease
- blood pressure
- clinical practice
- healthcare
- type diabetes
- rectal cancer
- public health
- radical prostatectomy
- end stage renal disease
- ejection fraction
- squamous cell carcinoma
- percutaneous coronary intervention
- prostate cancer
- acute myocardial infarction
- chronic kidney disease
- case report
- atrial fibrillation
- palliative care
- cardiovascular events
- locally advanced
- radiation therapy
- robot assisted
- cardiovascular risk factors
- cardiac resynchronization therapy
- newly diagnosed
- drug induced
- aortic stenosis
- coronary artery bypass grafting
- aortic valve
- minimally invasive
- preterm birth
- peritoneal dialysis