Clinical Implications of Transcriptomic Changes After Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

Javier I J OrozcoJanie G GrumleyChikako MatsubaAyla O Manughian-PeterShu-Ching ChangGrace ChangFrancisco E GagoMatthew P SalomonDiego M Marzese

Published in: Annals of surgical oncology (2019)

The results of this study reveal significant transcriptomic changes induced by NAC and suggest that chemotherapy-induced gene expression changes observed early in therapy may be good predictors of response to NAC.

Keyphrases

neoadjuvant chemotherapy
gene expression
chemotherapy induced
single cell
transcription factor
locally advanced
lymph node
rna seq
sentinel lymph node
dna methylation
squamous cell carcinoma
rectal cancer
radiation therapy
bone marrow