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Hemorrhage and Sudden Death in a Cat with Pancreatic Hemangiosarcoma.

Corina TomaRoxana PopaMara-Georgiana HaralambieOana-Roxana HaralambieRaluca Marica
Published in: Veterinary sciences (2022)
A 15-year-old female, indoor, spayed, domestic shorthair cat was presented for post-mortem evaluation with a history of sudden death. A red-brown 3 cm x 4 cm neoplastic mass was identified within the body of the pancreas, along with multiple similar nodular structures within the omentum and liver. Associated lesions included hemoperitoneum, yellow discoloration of the peritoneal wall, and severe anemia. Spindle-shaped neoplastic cells exhibiting malignancy features, which occasionally contained within the cytoplasm haematoidin crystals and/or red blood cells, were observed during cytological examination. Histologically, the neoplastic cells were organized in short streams forming vascular spaces filled with erythrocytes. Immunohistochemically, the neoplastic cells were immunolabeled for vimentin and CD31, supporting the diagnosis of hemangiosarcoma. This report offers a complete post-mortem and histological evaluation of a rare tumor in cats with an unusual location and a comparative assessment of 3 anti-CD31 antibodies.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • chronic kidney disease
  • oxidative stress
  • signaling pathway
  • air pollution