Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma.

Fukiko Kawai-KitahataYasuhiro AsahinaShun KanekoJun TsuchiyaAyako SatoMasato MiyoshiTomoyuki TsunodaEmi Inoue-ShinomiyaMiyako MurakawaSayuri NittaYasuhiro ItsuiMina NakagawaSeishin AzumaSei KakinumaMinoru TanabeEmiko SugawaraAkira TakemotoHidenori OjimaMichiie SakamotoMasaru MuraokaShinichi TakanoShinya MaekawaNobuyuki EnomotoMamoru Watanabe

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2019)

The genomic features of CLC and the focal area of an HCC-like region differ, but are related to the kinase-RAS module. The development of carcinogenesis in the CLC and HCC-like areas in this case might differ, following a common PTEN mutation, although alteration of the kinase-RAS module is the most common molecular event in CLC.

Keyphrases

wild type
protein kinase
tyrosine kinase
cell proliferation
copy number
pi k akt
gene expression
dna methylation
signaling pathway