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Alzheimer's cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans : CSF AD biomarkers measured by Lumipulse in Koreans.

Sohee MoonSujin KimSakulrat MankhongSeong Hye ChoiManu VandijckVesna KostanjeveckiJee Hyang JeongSoo Jin YoonKyung Won ParkEun-Joo KimBora YoonHee Jin KimJae-Won JangJin Yong HongDong-Ho ParkLeslie M ShawJu-Hee Kang
Published in: Alzheimer's research & therapy (2021)
CSF AD biomarkers measured by different immunoassay platforms show strong intercorrelated agreement with Aβ-PET in Koreans. The Korean-specific Aβ-PET-based CSF biomarker cutoffs measured by the Lumipulse assay strongly predicts progression of cognitive decline. The clinical utility of CSF biomarkers from fully-automated immunoassay platforms should be evaluated in larger, more diverse cohorts.
Keyphrases
  • cognitive decline
  • sensitive detection
  • computed tomography
  • high throughput
  • pet ct
  • mild cognitive impairment
  • positron emission tomography
  • machine learning
  • deep learning
  • pet imaging
  • cerebrospinal fluid