Alzheimer's cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans : CSF AD biomarkers measured by Lumipulse in Koreans.
Sohee MoonSujin KimSakulrat MankhongSeong Hye ChoiManu VandijckVesna KostanjeveckiJee Hyang JeongSoo Jin YoonKyung Won ParkEun-Joo KimBora YoonHee Jin KimJae-Won JangJin Yong HongDong-Ho ParkLeslie M ShawJu-Hee KangPublished in: Alzheimer's research & therapy (2021)
CSF AD biomarkers measured by different immunoassay platforms show strong intercorrelated agreement with Aβ-PET in Koreans. The Korean-specific Aβ-PET-based CSF biomarker cutoffs measured by the Lumipulse assay strongly predicts progression of cognitive decline. The clinical utility of CSF biomarkers from fully-automated immunoassay platforms should be evaluated in larger, more diverse cohorts.