Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common.

Isain ZapataLuis E MoraesElise M FialaSara Zaldivar-LopezC Guillermo CoutoJennie L RowellCarlos E Alvarez

Published in: BMC genomics (2019)

Polygenic osteosarcoma-risk commonly rises to Mendelian-levels in some dog breeds. This justifies caninized animal models and targeted clinical trials in pet dogs (e.g., using CDK4/6 and FGFR1/2 inhibitors).

Keyphrases

clinical trial
computed tomography
magnetic resonance imaging
cell cycle
positron emission tomography
genome wide
cancer therapy
study protocol
genetic diversity
contrast enhanced