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Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank.

Shan LuoShiu Lun Au YeungJie V ZhaoStephen BurgessCatherine Mary Schooling
Published in: BMJ (Clinical research ed.) (2019)
Endogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men. Rates of these conditions are higher in men than women. Endogenous testosterone can be controlled with existing treatments and could be a modifiable risk factor for thromboembolism and heart failure.
Keyphrases
  • heart failure
  • left ventricular
  • replacement therapy
  • cardiac resynchronization therapy
  • acute heart failure
  • polycystic ovary syndrome
  • type diabetes
  • smoking cessation
  • insulin resistance