Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview.
Meisam GachpazanIman AkhlaghipourHamid Reza RahimiEhsan SaburiMajid MojarradMohammad Reza AbbaszadeganMeysam MoghbeliPublished in: Auto- immunity highlights (2021)
Apart from the reported cytokines and chemokines, it was interestingly observed that the apoptosis related genes and non-coding RNAs were the most reported genetic abnormalities associated with SLE progression among Iranians. This review clarifies the genetics and molecular biology of SLE progression among Iranian cases. Moreover, this review paves the way of introducing an efficient panel of genetic markers for the early detection and better management of SLE in this population.
Keyphrases
- cell death
- systemic lupus erythematosus
- cell cycle arrest
- disease activity
- end stage renal disease
- genome wide
- ejection fraction
- chronic kidney disease
- copy number
- newly diagnosed
- rheumatoid arthritis
- prognostic factors
- peritoneal dialysis
- single molecule
- gene expression
- patient reported outcomes
- cell proliferation
- endoplasmic reticulum stress
- patient reported
- signaling pathway