C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.
Edwin K S WongKevin J MarchbankHannah Lomax-BrowneIsabel Y PappworthHarriet DentonKatie CookeSophie WardAmy-Claire McLoughlinGrant RichardsonValerie WilsonClaire Louise HarrisB Paul MorganSvetlana HakobyanPaul McAlindenDaniel P GaleHeather MaxwellMartin ChristianRoger MalcomsonTimothy H J GoodshipStephen D MarksMatthew Caleb PickeringDavid KavanaghH Terence CookSally A Johnsonnull nullPublished in: Clinical journal of the American Society of Nephrology : CJASN (2021)
Crescentic disease was a key risk factor associated with kidney failure in a national cohort of pediatric patients with membranoproliferative GN/C3 glomerulopathy and immune-complex GN. Presenting eGFR and crescentic disease help define prognostic groups in pediatric C3 glomerulopathy. Acquired abnormalities of the alternative pathway were commonly identified but not a risk factor for kidney failure.