The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression.
Alessandra CapuanoMaddalena VescovoSimone CanesiEliana PivettaRoberto DolianaMaria Grazia NadinMasami YamamotoTetsuya TsukamotoSachiyo NomuraEmanuela PilozziAntonio PalumboVincenzo CanzonieriRenato CannizzaroEugenio ScanzianiGustavo BaldassarreMaurizio MongiatPaola SpessottoPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)
This study demonstrates for the first time that loss of EMILIN-1 in GC leads to lymphatic dysfunction and proliferative advantages that sustain tumorigenesis, and assess the use of our animal model as a valuable tool to verify the fate of GC upon loss of EMILIN-1.