Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice.
Qingyi ZhangZeyu CaiZhewei YuChang DiYingkun QiuRong QiPublished in: Cardiovascular drugs and therapy (2023)
Through suppressing NF-κB/NLRP3 pathway activation, AD effectively mitigates the inflammatory response in VSMCs, mitigates inflammation in aortas, prevents extracellular matrix degradation, and consequently impedes the progression of AAA. AO emerges as one of the active compounds in AD responsible for inhibiting VSMC inflammation and inhibiting AAA development.
Keyphrases
- extracellular matrix
- signaling pathway
- oxidative stress
- abdominal aortic aneurysm
- inflammatory response
- lps induced
- pi k akt
- lipopolysaccharide induced
- radiation induced
- toll like receptor
- high fat diet induced
- type diabetes
- vascular smooth muscle cells
- molecularly imprinted
- immune response
- insulin resistance
- high resolution
- skeletal muscle