Induction of resistance to neurotrophic tropomyosin-receptor kinase inhibitors by HMGCS2 via a mevalonate pathway.

Yasuhiro Kato Masaru MatsumotoNatsuki TakanoMariko HiraoKuniko MatsudaTakehiro Tozuka Naomi OndaShinji NakamichiSusumu Takeuchi Akihiko MiyanagaRintaro NoroAkihiko GemmaMasahiro Seike

Published in: Cancer medicine (2024)

These results suggest that HMGCS2 overexpression induces resistance to NTRK-TKIs via the mevalonate pathway in colon cancer cells. Statin inhibition of the mevalonate pathway may be useful for overcoming this mechanistic resistance.

Keyphrases

cardiovascular disease
coronary artery disease
cell proliferation
transcription factor
binding protein