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Plasma from healthy donors protects blood-brain barrier integrity via FGF21 and improves the recovery in a mouse model of cerebral ischaemia.

Muyassar MamtilahunLu JiangYaying SongXiaojing ShiChang LiuYixu JiangLidong DengHaoran ZhengHui ShenYongfang LiZhijun ZhangYongting WangYaohui TangYongting Wang
Published in: Stroke and vascular neurology (2021)
Our study demonstrated that healthy adult plasma treatment protected the structural and functional integrity of blood-brain barrier, reduced neuronal apoptosis and improved functional recovery via FGF21, opening a new avenue for ischaemic stroke therapy.
Keyphrases
  • blood brain barrier
  • cerebral ischemia
  • mouse model
  • oxidative stress
  • endoplasmic reticulum stress
  • subarachnoid hemorrhage
  • cell death
  • cell cycle arrest
  • brain injury
  • kidney transplantation
  • combination therapy