Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.

Lucile P A NeytonPratik SinhaAartik SarmaEran MickKatrina KalantarStephanie ChenNelson WuKevin DelucchiHanjing ZhuoLieuwe D J BosAlejandra JaureguiAntonio GomezCarolyn M HendricksonKirsten N KangelarisAleksandra LeligdowiczKathleen D LiuMichael A MatthayCharles R LangelierCarolyn S Calfee

Published in: American journal of respiratory and critical care medicine (2024)

The hyperinflammatory and hypoinflammatory phenotypes have distinct transcriptional and metagenomic features that could be leveraged for precision treatment strategies.

Keyphrases

gene expression
transcription factor
antibiotic resistance genes
heat shock
oxidative stress
microbial community