Low oxygen levels decrease adaptive immune responses and ameliorate experimental asthma in mice.

Mathias Hochgerner Eva Maria SturmDiana SchnoeglGrazyna Kwapiszewska Horst Olschewski Leigh Matthew Marsh

Published in: Allergy (2021)

Hypoxia-induced reduction in the Th2-response to HDM ameliorates allergic asthma in vivo. Hypoxia interferes with APC/T-cell crosstalk and confers an unresponsive phenotype to APCs.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
immune response
lung function
toll like receptor
cystic fibrosis
type diabetes
dendritic cells
metabolic syndrome
adipose tissue