Age-Related Macular Degeneration and Its Genetic Risk: A Population-based Study.
Davide GarzoneMohammed Aslam ImtiazMatthias M MauschitzN Ahmad AzizFrank G HolzMonique M B BretelerRobert P FingerPublished in: Current eye research (2024)
In a population-based setting, we confirmed higher genetic risk to be associated with more severe AMD and identified associations with high-risk features of intermediate AMD. Conjoint analyses suggested that high-risk features and late AMD might be differentially associated with genetic architecture in AMD, such as ECM remodeling. Incorporation of genetic information such as GRSs might improve AMD risk prediction strategies.