A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(IV) prodrugs.

Published in: Dalton transactions (Cambridge, England : 2003) (2022)

We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(IV) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(IV) complex in cell extracts.

Keyphrases

living cells
single molecule
fluorescent probe
sensitive detection
single cell
energy transfer
quantum dots
cell therapy
stem cells
high intensity
bone marrow
mesenchymal stem cells