Aptamer proteomics of serum exosomes from patients with Primary Raynaud's and patients with Raynaud's at risk of evolving into Systemic Sclerosis.
Sonsoles Piera-VelazquezSimon T DillonXuesong GuTowia A LibermannSergio A JimenezPublished in: PloS one (2022)
Aptamer proteomic analysis of circulating exosomes identified differentially elevated or reduced proteins between Raynaud's Phenomenon at high risk of evolving into SSc and Primary Raynaud's Phenomenon patients. Some of these proteins are involved in relevant biological pathways that may play a role in SSc pathogenesis including enhanced inflammatory responses, immune cell activation, and endothelial cell and vascular abnormalities.
Keyphrases
- systemic sclerosis
- label free
- interstitial lung disease
- end stage renal disease
- mesenchymal stem cells
- stem cells
- gold nanoparticles
- ejection fraction
- chronic kidney disease
- endothelial cells
- sensitive detection
- peritoneal dialysis
- mass spectrometry
- prognostic factors
- magnetic nanoparticles
- rheumatoid arthritis
- patient reported outcomes
- idiopathic pulmonary fibrosis