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Finding Wealth in Waste: Irreplicability Re-Examined.

Bart PendersA Cecile J W Janssens
Published in: BioEssays : news and reviews in molecular, cellular and developmental biology (2018)
Irreplicability is framed as crisis, blamed on sloppy science motivated by perverse stimuli in research. Structural changes to the organization of science, targeting sloppy science (e.g., open data, pre-registration), are proposed to prevent irreplicability. While there is an unquestionable link between sloppy science and failures to replicate/reproduce scientific studies, they are currently conflated. This position can be understood as a result of the erosion of the role of theory in science. The history, sociology, and philosophy of science reveal alternative explanations for irreplicability to show it is part of proper, informative and valuable science. Irreplicability need not equate research waste. Sloppy science is the problem, also when results do replicate. Hence, the solution should focus on opposing sloppy research.
Keyphrases
  • public health
  • gene expression
  • machine learning
  • dna methylation
  • deep learning
  • sewage sludge
  • data analysis