Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria.

Kero GuynesLuke A SarreAllan M Carrillo-BaltodanoBillie E DaviesLan XuYan LiangFrancisco M Martín-ZamoraPaul J HurdAlex de MendozaJosé María Martín-Durán

Published in: Genome biology (2024)

Our study indicates that global epigenetic erosion during development and aging is an ancestral feature of bilateral animals. However, the tight link between transcription and gene body methylation is likely more important in early embryonic stages, and 5mC-mediated TE silencing probably emerged convergently across animal lineages.

Keyphrases

dna methylation
genome wide
gene expression
machine learning
blood brain barrier
copy number
transcription factor
deep learning