GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer.
Xuejie WangFeng BaiXiong LiuBin PengXingzhi XuHongquan ZhangLi FuWei-Guo ZhuBin WangXin-Hai PeiPublished in: BMC biology (2024)
These results demonstrate that Gata3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in mammary tumorigenesis and progression. Our findings suggest that PARP inhibitors are effective for the treatment of GATA3-deficient BLBCs.