Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.

Aarthi RavindranLari HolappaHenri NiskanenIlya SkovorodkinSusanna KaistoMustafa BeterMiika KiemaIlakya SelvarajanValtteri NurminenEinari AavikRédouane AherrahrouSanna Pasonen-SeppänenVittorio FortinoJohanna P LaakkonenSuo Ctc Bladder CommitteeSeppo VainioTiit ÖrdMinna U Kaikkonen

Published in: Cardiovascular research (2024)

We generated a SMC-specific TRAP mouse line to study atherosclerosis and identified Itih4 as a novel SMC-expressed gene in atherosclerotic plaques, warranting further investigation of its putative function in extracellular matrix stability and genetic evidence of causality.

Keyphrases

extracellular matrix
smooth muscle
genome wide
copy number
single cell
cardiovascular disease
genome wide identification
cell therapy
dna methylation
type diabetes
transcription factor
bone marrow