Thymoquinone and quercetin protect against hepatic steatosis in association with SIRT1/AMPK stimulation and regulation of autophagy, perilipin-2, and cytosolic lipases.
Hend AshourLaila Ahmed RashedRadwa T M HassaneinBasma Emad AboulhodaHasnaa Ali EbrahimMohamed H ElsayedMiran Atif ElkordyOmaima M AbdelwahedPublished in: Archives of physiology and biochemistry (2022)
TQ and quercitin effectively upregulated SIRT1/p-AMPK and regulated hepatic perilipin-2/ATGL, inflammation and oxidative stress, preserved liver structure and function. TQ/quercetin combination additively prevents HS.