Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer.
Longqiang WangXin TongZhengyu ZhouShengjie WangZhe LeiTianze ZhangZeyi LiuYuanyuan ZengChang LiJun ZhaoZhiyue SuCuijuan ZhangXia LiuGuangquan XuHong-Tao ZhangPublished in: Molecular cancer (2018)
Our findings show that circPTK2 (hsa_circ_0008305) inhibits TGF-β-induced EMT and metastasis by controlling TIF1γ in NSCLC, revealing a novel mechanism by which circRNA regulates TGF-β-induced EMT and tumor metastasis, and suggesting that circPTK2 overexpression could provide a therapeutic strategy for advanced NSCLC.