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Incremental value of blood-based markers of liver fibrosis in cardiovascular risk stratification.

Georgios GeorgiopoulosStavros AthanasopoulosGeorgios MavraganisChristina KonstantakiMaria PapaioannouDimitrios DelialisLasthenis AngelidakisMarco SachseDimitrios PapoutsisBeyza CavlanSimon Tual-ChalotGeorgios ZervasKateryna SopovaAsimina MitrakouKonstantinos StellosKimon Stamatelopoulos
Published in: The Journal of clinical endocrinology and metabolism (2024)
In a cardio-metabolically diverse population, the incremental associations of LFNITs with CVD outcomes were mediated by atherosclerotic burden rather than arterial stiffening. FIB-4 consistently demonstrated associations with all study endpoints. These findings provide mechanistic insights and support the clinical applicability of FIB-4 in CVD prevention.
Keyphrases
  • liver fibrosis
  • type diabetes
  • metabolic syndrome