The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters.
Alexander D McHughJ Geoffrey ChaseJennifer L Knopp Nee DicksonJennifer J OrmsbeeDiana G KulawiecTroy L MerryRinki MurphyPeter R ShepherdHannah J BurdenPaul D DochertyPublished in: Journal of diabetes science and technology (2021)
A small 1-U insulin bolus improves identification of hepatic clearance parameters by providing a smaller region of optimal parameter values. Adding an insulin bolus in metabolic tests can significantly improve identifiability and outcome test precision. Assay errors necessitate insulin modification in clinical tests to ensure identifiability and precision.