SGLT2 inhibition promotes glomerular repopulation by cells of renin lineage in experimental kidney disease.

Loïs A K van der PluijmAngela KoudijsWendy StamJoris J T H RoelofsA H Jan DanserJoris I RotmansKenneth W GrossMichael P PieperAnton Jan van ZonneveldRoel Bijkerk

Published in: Acta physiologica (Oxford, England) (2024)

We conclude that SGLT2 inhibition by empagliflozin promotes CoRL-mediated glomerular repopulation with selective CoRL-derived cell types depending on the type of experimental kidney injury. These findings suggest a previously unidentified mechanism that could contribute to the renoprotective effect of SGLT2 inhibitors.

Keyphrases

diabetic nephropathy
single cell
induced apoptosis
cell cycle arrest
high glucose
cell therapy
stem cells
cell death
endoplasmic reticulum stress
oxidative stress
mesenchymal stem cells
endothelial cells
signaling pathway
bone marrow