The amazing axolotl: robust kidney regeneration following acute kidney injury.
Elysa Ng May MayRebecca A WingertPublished in: Tissue barriers (2023)
The incidence of kidney disease from acute and chronic conditions continues to escalate worldwide. Interventions to replace renal function after organ failure remain limited to dialysis or transplantation, as human kidneys exhibit a limited capacity to repair damaged cells or regenerate new ones. In contrast, animals ranging from flies to fishes and even some mammals like the spiny mouse exhibit innate abilities to regenerate their kidney cells following injury. Now, a recent study has illuminated how the Mexican salamander, Ambystoma mexicanum , most commonly known as the axolotl, possesses a kidney with remarkable similarity to humans, which can robustly regenerate following acute chemical damage. These discoveries position the axolotl as a new model that can be used to advance our understanding about the fundamental mechanisms of kidney regeneration.
Keyphrases
- induced apoptosis
- acute kidney injury
- liver failure
- stem cells
- cell cycle arrest
- respiratory failure
- immune response
- endothelial cells
- drug induced
- oxidative stress
- physical activity
- magnetic resonance
- chronic kidney disease
- magnetic resonance imaging
- cardiac surgery
- computed tomography
- pi k akt
- cell proliferation
- mesenchymal stem cells