Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration.

Zhiyu ZhouStephan ZeiterTanja SchmidDaisuke SakaiJames C IatridisGuangqian ZhouR Geoff RichardsMauro AliniSibylle GradZhen Li

Published in: Cartilage (2018)

CCL5 has a chemotactic effect on AF cells in vitro, but no ex vivo or in vivo regenerative effect when delivered within fibrin gel. Further study with a stronger chemotactic agent and/or an alternate biomaterial that is more conductive of cell migration is warranted.

Keyphrases

cell migration
stem cells
induced apoptosis
liver injury
mesenchymal stem cells
tissue engineering
wound healing
atrial fibrillation
drug induced
platelet rich plasma
hyaluronic acid
oxidative stress
gold nanoparticles