Carbamoyl Fluoride-Enabled Enantioselective Ni-Catalyzed Carbocarbamoylation of Unactivated Alkenes.

Yue LiFeng-Ping ZhangRong-Hua WangShao-Long QiYu-Xin Luan Mengchun Ye

Published in: Journal of the American Chemical Society (2020)

A carbamoyl fluoride-enabled enantioselective Ni-catalyzed carbocarbamoylation of unactivated alkenes was developed, providing a broad range of chiral γ-lactams bearing an all-carbon quaternary center in 45-96% yield and 38-97% ee.

Keyphrases

room temperature
drinking water
ionic liquid
metal organic framework
transition metal
capillary electrophoresis